Focus on Healthy Aging - Two-drug combo may improve overactive bladder in some men
An estimated 10 million men age 40 and older have to contend with overactive bladder–an urgent and frequent need to urinate. Often, the cause of the problem is benign prostatic hyperplasia (BPH)–an enlargement of the prostate that can obstruct the bladder opening. A study in the November 15 Journal of the American Medical Association finds that a combination of two drugs–tolterodine (Detrol LA), which is used to treat urinary problems, and tamsulosin (Flomax), which is used to treat BPH symptoms–shows real benefit for treating men with overactive bladder.
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Researchers randomized more than 850 men (average age, 62) with moderate-to-severe overactive bladder to one of four treatment groups: one daily 4 mg dose of tolterodine, one daily 0.4 mg dose of tamsulosin, the two drugs in combination, or a placebo. After 12 weeks, 80 percent of the men who were taking both drugs reported improvements in their urinary symptoms, compared to 71 percent in the tamsulosin group, 65 percent in the tolterodine group, and 62 percent in the control group. For some men with overactive bladder, tamsulosin may be enough to ease symptoms, but others may need to take both drugs.
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